Anne Rowley, MD
Dr. Anne Rowley attended SUNY Upstate Medical School and performed her pediatric residency training at the Children’s Hospital of Pittsburgh. She was a fellow in pediatric infectious diseases at The Children’s Memorial Hospital in Chicago, and is now an attending physician in the Division of Infectious Diseases, The Children’s Memorial Hospital, and Professor of Pediatrics and of Microbiology/Immunology at Northwestern University Feinberg School of Medicine.

She has served on the Subboard of Pediatric Infectious Diseases of the American Board of Pediatrics, and on the Council of the Pediatric Infectious Diseases Society. She is an elected member of the Society for Pediatric Research and the American Pediatric Society. She has been funded by the National Institutes of Health for Kawasaki Disease research since 1995. Her laboratory is one of the very few in the United States focused entirely on Kawasaki Disease etiology and pathogenesis. She has published 58 peer-reviewed articles and about 50 invited reviews/book chapters on Kawasaki Disease.

Current Research Project

February, 2010 was awarded a grant from NIH to continue her pursuit of finding the cause of Kawasaki Disease

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The Pathogenesis of Kawasaki Disease
The major goals of this proposal are to identify the cell and tissue types in which cytoplasmic inclusion bodies form in acute KD, and search these cells/tissues for microbial elements by transmission electron microscopy, to identify the nucleic acid/protein contents of KD cytoplasmic inclusion bodies; and to determine whether dysregulation of members of the tumor necrosis factor (TNF)- and TNF-receptor superfamily contribute to KD vasculopathy.

Completed Projects

Cloning Kawasaki Disease-specific antigens
05/01/2001-04/30/2006
The major goals of this proposal are to make synthetic antibodies from prevalent IgA sequences in
Kawasaki vascular tissue and use them as reagents to determine antigens involved in Kawasaki
Disease pathogenesis.
Bronchial Epithelial Cell Cultures in Kawasaki Disease
4/1/2008-3/31/2011
The major goals of this proposal are to determine if clinical respiratory samples from acute KD patients
infect ciliated bronchial epithelial cell cultures in vitro and to use sequence-independent amplification
techniques to amplify, clone, and sequence novel nucleic acid sequences from the cell-free supernatant of
the cultures.